CAS 131707-23-8,Arbidol Hydrochloride (HCL)

A key step in the synthesis of arbidol hydrochloride Cas number 131707-23-8 is the construction of an anthracene ring, which is generally a ring-forming reaction by Nenitzescu, a condensation ring of p-benzoquinone with 3-hydrocarbylamino-2-butenoate. On this basis, through the acylation reaction, bromination reaction, deprotection reaction, nucleophilic substitution with thiophenol, Mannich amination, salt formation seven-step reaction, finally obtained arbidol hydrochloride Cas number 131707-23-8. Most of the other routes have undergone a certain degree of change on this basis. In another method, 3-iodo-4-nitrophenol is used as a raw material, which is protected by a hydroxyl group, and is substituted with ethyl acetoacetate under a base to synthesize an anthracene ring, methylation, and bromine by a reduction-condensation reaction. , thiophenolation, Mannich amine methylation, hydrochloric acid acidification, refined to obtain abidol hydrochloride. The method has the advantages…

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