Polyphosphoric Acid is an inorganic compound with the chemical formula Hn+2PnO3n+1. It is a colorless, transparent, viscous liquid that is corrosive and classified as a Class 2 inorganic acid corrosive substance. Polyphosphoric acid is a protonic acid and can dissolve various low-molecular-weight and high-molecular-weight organic compounds.
PRODUCT APPLICATION
Polyphosphoric acid (PPA) is used as a cyclodehydration aid for organic synthesis.
◆ Single-step dehydration instead of a two-step inverse Friedel-Crafts
synthesis (formation of the acid chloride, followed by condensation),
can improve target molecule yield with no need for halogens.
◆ In many cases, replacing a sulfuric/phosphoric acid dehydration reaction medium with PPA will result in higher yields.
◆ Seven-membered ring compounds can be assembled with a reduced risk of
ester cleavage or incorporating molecules of the dehyd…